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March 26, 2016
Table of Contents

1 Introduction



Fibrosis is the formation or development of excess fibrous connective tissue in an organ or tissue as a reparative or reactive process, as opposed to a formation of fibrous tissue as a normal constituent of an organ or tissue. Scarring is confluent fibrosis that obliterates the architecture of the underlying organ or tissue.

The term is also sometimes used to describe a normal healing process, but this usage is less common.

  • Pulmonary fibrosis (lungs)

  • * Idiopathic pulmonary fibrosis (where the cause is unknown)

  • Cirrhosis (liver)

  • Endomyocardial fibrosis (heart)

  • Mediastinal fibrosis (soft tissue of the mediastinum)

  • Myelofibrosis (bone marrow)

  • Retroperitoneal fibrosis (soft tissue of the retroperitoneum)

  • Progressive massive fibrosis (lungs); a complication of coal workers' pneumoconiosis

  • Nephrogenic systemic fibrosis (skin)

  • Keloid (skin)

  • Scleroderma/ systemic sclerosis (skin, lungs)

TypeMost common location(s)CircumscriptionCellularityVascularity and nature of vesselsAppearance of collagen Elastic fibers Picture
Nuchal fibromaNuchal region No Very low Very low Bundles of fibers Scant Image:NuchalFibroma.jpg|center|100px
Collagenous fibromaShoulder girdle, extremities Yes, by macroscopic appearance, but microscopically infiltrative Increased but generally low Low Scant or absent Amorphous -Fibroma of tendon sheathDistal extremities, especially the hand Yes Low to highModerate to high, with some slitlike vessels Amorphous Absent Image:FibromaOfTendonSheath.JPG|center|100px
Scar Variable Variable Low to high Variable Amorphous Scant to absent Image:ScarHistology.JPG|center|100px
ElastofibromaSubscapular chest wall No Low to moderate Low Amorphous Abundant and abnormal Image:Elastofibroma1.JPG|center|100pxImage:ElastofibromaStain.jpg|center|100px
Desmoid-type fibromatosisAbdominal wall, shoulder girdleYes, by macroscopic appearance, but microscopically infiltrative Moderate Moderate, mildly dilated Amorphous Absent Image:DesmoidFibromatosis.JPG|center|100px
KeloidUpper part of back, deltoid, presternal, ear lobesNoSome fibroblastsLowAmorphous thick eosinophilic bundlesScant or AbsentImage:KeloidHistology.JPG|center|100px

  • International Scar Meeting in Tokyo 2010 International Scar Meeting

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "fibrotic".

Last Modified:   2010-11-30

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