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Thursday, February 15th, 2018
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 [F] Diseases Research  / PubMed Research Articles  /
Anarchy in the UPR: A Ca2+-insensitive PKC inhibits SERCA activity to promote ER stress.




Bioscience reports Feb ; ()


Schmitz-Peiffer C1;

Author Information
  • 1Diabetes and Metabolism Division, Garvan Institute of Medical Research, and St Vincents Clinical School, University of New South Wales, Darlinghurst, Sydney, 2010, Australia c.schmitz-peiffer@garvan.org.au.


Nonalcoholic fatty liver disease (NAFLD) is highly prevalent in Western countries, and is linked to the development of liver cancer and Type 2 diabetes (T2D). It is strongly associated with obesity, but the dysregulation of liver lipid storage is not fully understood. Fatty acid oversupply to hepatocytes can establish a vicious cycle involving diminished protein folding, endoplasmic reticulum (ER) stress, insulin resistance and further lipogenesis. This commentary discusses the recent findings of Laiet al.published in Bioscience Reports, that implicate protein kinase C delta (PKCδ) activation by fatty acids in the inhibition of the SERCA Ca2+pump, resulting in reduced ER Ca2+loading and protein misfolding. PKCδ therefore represents a target for the treatment of both steatosis and insulin resistance, key to the prevention of NAFLD and T2D.

©2018 The Author(s).




Publication Type: Journal Article

This article is licensed under the the National Library of Medicine License. It uses material from the PubMed National Library of Medicine Data.

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