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Thursday, February 15th, 2018
Table of Contents

1 Introduction
5 PMID
 [F] Diseases Research  / PubMed Research Articles  /
Psychological Outcomes following a nurse-led Preventative Psychological Intervention for critically ill patients (POPPI): protocol for a cluster-randomised clinical trial of a complex intervention.

PubMed

 

Resource

BMJ open 02 ; 8(2)

Authors

Richards-Belle A1; Mouncey PR2; Wade D3; Brewin CR4; Emerson LM5; Grieve R6; Harrison DA7; Harvey S8; Howell D9; Mythen M10; Sadique Z11; Smyth D12; Weinman J13; Welch J14; Rowan KM15; POPPI Trial Investigators16;

Author Information
  • 1Clinical Trials Unit, Intensive Care National Audit & Research Centre (ICNARC), London, UK.
  • 2Clinical Trials Unit, Intensive Care National Audit & Research Centre (ICNARC), London, UK.
  • 3Critical Care Department, University College London Hospitals NHS Foundation Trust, London, UK.
  • 4Research Department of Clinical, Educational & Health Psychology, University College London, London, UK.
  • 5Centre for Experimental Medicine, Queen's University Belfast, Belfast, UK.
  • 6Department of Health Services Research and Policy, London School of Hygiene & Tropical Medicine, London, UK.
  • 7Clinical Trials Unit, Intensive Care National Audit & Research Centre (ICNARC), London, UK.
  • 8Clinical Trials Unit, Intensive Care National Audit & Research Centre (ICNARC), London, UK.
  • 9Critical Care Department, University College London Hospitals NHS Foundation Trust, London, UK.
  • 10NIHR Biomedical Research Centre, University College London/University College London Hospitals, Institute of Sport Exercise and Health (ISEH), London, UK.
  • 11Department of Health Services Research and Policy, London School of Hygiene & Tropical Medicine, London, UK.
  • 12Critical Care Department, University College London Hospitals NHS Foundation Trust, London, UK.
  • 13Institute of Pharmaceutical Science, King's College London, London, UK.
  • 14Critical Care Department, University College London Hospitals NHS Foundation Trust, London, UK.
  • 15Clinical Trials Unit, Intensive Care National Audit & Research Centre (ICNARC), London, UK.

Abstract

INTRODUCTION: Acute psychological stress, as well as unusual experiences including hallucinations and delusions, are common in critical care unit patients and have been linked to post-critical care psychological morbidity such as post-traumatic stress disorder (PTSD), depression and anxiety. Little high-quality research has been conducted to evaluate psychological interventions that could alleviate longer-term psychological morbidity in the critical care unit setting. Our research team developed and piloted a nurse-led psychological intervention, aimed at reducing patient-reported PTSD symptom severity and other adverse psychological outcomes at 6 months, for evaluation in the POPPI trial.

METHODS AND ANALYSIS: This is a multicentre, parallel group, cluster-randomised clinical trial with a staggered roll-out of the intervention. The trial is being carried out at 24 (12 intervention, 12 control) NHS adult, general, critical care units in the UK and is evaluating the clinical effectiveness and cost-effectiveness of a nurse-led preventative psychological intervention in reducing patient-reported PTSD symptom severity and other psychological morbidity at 6 months. All sites deliver usual care for 5 months (baseline period). Intervention group sites are then trained to carry out the POPPI intervention, and transition to delivering the intervention for the rest of the recruitment period. Control group sites deliver usual care for the duration of the recruitment period. The trial also includes a process evaluation conducted independently of the trial team.

ETHICS AND DISSEMINATION: This protocol was reviewed and approved by the National Research Ethics Service South Central - Oxford B Research Ethics Committee (reference: 15/SC/0287). The first patient was recruited in September 2015 and results will be disseminated in 2018. The results will be presented at national and international conferences and published in peer reviewed medical journals.

TRIAL REGISTRATION NUMBER: ISRCTN53448131; Pre-results.

© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

PMID

29439083

Others

Publication Type: Journal Article, Research Support, Non-U.S. Gov't


This article is licensed under the the National Library of Medicine License. It uses material from the PubMed National Library of Medicine Data.


Last Modified:   2016-03-27


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