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Thursday, February 15th, 2018
Table of Contents

1 Introduction
5 PMID
 [F] Diseases Research  / PubMed Research Articles  /
Association of fetuin-A with incident type 2 diabetes: Results from the MONICA/KORA Augsburg study and a systematic meta-analysis.

PubMed

 

Resource

European journal of endocrinology Feb ; ()

Authors

Sujana C1; Huth C2; Zierer A3; Meesters S4; Sudduth-Klinger J5; Koenig W6; Herder C7; Peters A8; Thorand B9;

Author Information
  • 1C Sujana, Institute for Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians Universität, Munich, Germany.
  • 2C Huth, Institute of Epidemiology II, Helmholtz Zentrum Munchen Deutsches Forschungszentrum fur Umwelt und Gesundheit, Neuherberg, Germany.
  • 3A Zierer, Institute of Epidemiology II, Helmholtz Zentrum Munchen Deutsches Forschungszentrum fur Umwelt und Gesundheit, Neuherberg, Germany.
  • 4S Meesters, Institute of Epidemiology II, Helmholtz Zentrum Munchen Deutsches Forschungszentrum fur Umwelt und Gesundheit, Neuherberg, Germany.
  • 5J Sudduth-Klinger, ,, Tethys Bioscience Inc, Emeryville, United States.
  • 6W Koenig, Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.
  • 7C Herder, ,, German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany.
  • 8A Peters, Institute of Epidemiology II, Helmholtz Zentrum Munchen Deutsches Forschungszentrum fur Umwelt und Gesundheit, Neuherberg, Germany.
  • 9B Thorand, Institute of Epidemiology II, Helmholtz Zentrum Munchen Deutsches Forschungszentrum fur Umwelt und Gesundheit, Neuherberg, Germany thorand@helmholtz-muenchen.de.

Abstract

Objective We investigated the association of circulating fetuin-A with incident T2D particularly examining potential sex differences. Additionally, we determined whether putative associations were independent of subclinical inflammation, adiponectin and liver fat content. Design Case-cohort study plus systematic meta-analysis. Methods We investigated the association between baseline fetuin-A levels and incident T2D in the MONICA/KORA Augsburg study using Cox proportional hazards analyses. Furthermore, we conducted a systematic review within PUBMED and EMBASE and pooled association estimates of eligible studies with the MONICA/KORA Augsburg data using a DerSimonian-Laird random effects model. Results Within MONICA/KORA Augsburg, 930 participants developed incident T2D (median follow-up: 14 years). We observed a significant association between fetuin-A and T2D risk after multivariable adjustment including C-reactive protein and adiponectin. The strength of the association was similar in males and females (P-value for sex interaction >0.55). Seven eligible published studies were identified in addition to the MONICA/KORA Augsburg study for the meta-analysis. The pooled hazard ratio (95% CI) for incident T2D per 1 standard deviation (SD) increment of fetuin-A was 1.24 (1.14-1.34) for the multivariable adjusted model. Our sex-stratified meta-analysis yielded relative risk estimates per 1 SD of 1.19 (1.04-1.38) in males and 1.29 (1.15-1.46) in females. Further individual adjustment for subclinical inflammation, adiponectin and liver fat content had almost no impact on the strength of the association. Conclusions Higher fetuin-A levels are associated with incident T2D in both males and females independently of subclinical inflammation, adiponectin, and liver fat content.



PMID

29439057

Others

Publication Type: Journal Article


This article is licensed under the the National Library of Medicine License. It uses material from the PubMed National Library of Medicine Data.


Last Modified:   2016-03-27


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