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Thursday, February 15th, 2018
Table of Contents

1 Introduction
5 PMID
 [F] Diseases Research  / PubMed Research Articles  /
Hippocampal ripples down-regulate synapses.

PubMed

 

Resource

Science (New York, N.Y.) Feb ; ()

Authors

Norimoto H1; Makino K2; Gao M3; Shikano Y4; Okamoto K5; Ishikawa T6; Sasaki T7; Hioki H8; Fujisawa S9; Ikegaya Y10;

Author Information
  • 1Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
  • 2Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
  • 3Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
  • 4Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
  • 5Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
  • 6Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
  • 7Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
  • 8Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • 9Laboratory for Systems Neurophysiology, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako City, Saitama, 351-0198, Japan. yuji@ikegaya.jp fujisawa@brain.riken.jp.
  • 10Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan. yuji@ikegaya.jp fujisawa@brain.riken.jp.

Abstract

The functions of sleep for synaptic plasticity remain elusive. We report that mouse hippocampal sharp wave/ripple oscillations serve as intrinsic events that trigger long-lasting synaptic depression. Silencing of sharp waves/ripples during slow-wave states prevented the spontaneous downregulation of net synaptic weights and impaired the learning of new memories. The synaptic downregulation wasN-methyl-d-aspartate receptor-dependent and input pathway-selective. Thus, our findings are consistent with the role of slow-wave states in refining memory engrams by reducing recent memory-irrelevant neuronal activity and suggest a new role for sharp waves/ripples.

Copyright © 2018, American Association for the Advancement of Science.

PMID

29439023

Others

Publication Type: Journal Article


This article is licensed under the the National Library of Medicine License. It uses material from the PubMed National Library of Medicine Data.


Last Modified:   2016-03-27


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