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Thursday, February 15th, 2018
Table of Contents

1 Introduction
5 PMID
 [F] Diseases Research  / PubMed Research Articles  /
Pattern of breast cancer blood flow and metabolism, assessed using dual-acquisition18FDG PET: correlation with tumor phenotypic features and pathological response to neoadjuvant chemotherapy.

PubMed

 

Resource

Journal of nuclear medicine : official publication, Society of Nuclear Medicine Feb ; ()

Authors

Humbert O1; Lasserre M2; Bertaut A3; Fumoleau P4; Coutant C5; Brunotte F6; Cochet A7;

Author Information
  • 1Centre Antoine-Lacassagne, France.
  • 2Centre Georges-François Leclerc, France.
  • 3Centre Georges-François Leclerc, France.
  • 4Centre Georges-François Leclerc, France.
  • 5Centre Georges-François Leclerc, France.
  • 6Centre Georges-François Leclerc, France.
  • 7Centre Georges-François Leclerc, France.

Abstract

In breast cancer, early changes in tumor glucose metabolism and blood flow (BF) have been evaluated separately and are proposed to monitor tumor response to neoadjuvant chemotherapy (NAC). This study used a single18FDG dual-acquisitions PET exam to simultaneously assess these imaging features and to answer two questions: (i) Do tumor blood flow (BF) and tumor metabolism correlated with the same pre-therapy tumor phenotypic features? (ii) Are early changes in tumor BF and metabolism in response to NAC comparable or complementary in the ability to predict the pathological complete response (pCR)?Methods:150 women with breast cancer and an indication for NAC were prospectively included. Women had a baseline PET exam with a 2-min chest-centered dynamic acquisition, started at the time of18F-FDG injection, followed by a delayed static PET acquisition performed at 90 min. Tumor BF was calculated from the dynamic image using a validated first-pass model, and tumor glucose metabolism (SUVmax) was calculated on the delayed acquisition. This dual-PET acquisition was repeated after the first cycle of NAC to measure early changes in tumor BF (ΔBF) and SUVmax(ΔSUVmax).Results:A weak correlation was found between baseline tumor SUVmaxand BF (r= 0.22;P= 0.006). A higher baseline SUVmaxwas associated with all biological markers of tumor aggressiveness, including the Triple Negative Breast Cancer (TNBC) subtype (p<0.0001). In contrast, a high baseline tumor BF was only associated with obesity (P= 0.002). Mean ΔSUVmaxwas -44.6±27.4% and varied depending on the SBR grade, the overexpression of HER2+ and the lack of hormonal receptor expression (P= 0.04, p<0.001 andP= 0.01, respectively). Mean ΔBF was -26.9±54.3% and a drastic reduction was only observed in HER2-positive subtypes (-58.7±30.0%), supporting the anti-angiogenic effect of Trastuzumab. Changes in tumor glucose metabolism outperformed changes in BF to predict pCR in all tumor subtypes: The Areas Under the Curve of ΔSUVmaxwere 0.82, 0.65 and 0.90 in the TNBC, HER2-positive and Luminal subtypes, respectively.Conclusion:Of the two biological hallmarks of cancer evaluated in this study, the reduction in tumor metabolism was more accurate than the reduction in BF to predict pCR in the different subtypes of breast cancer.

Copyright © 2018 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

PMID

29439010

Others

Publication Type: Journal Article


This article is licensed under the the National Library of Medicine License. It uses material from the PubMed National Library of Medicine Data.


Last Modified:   2016-03-27


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