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Monday, February 12th, 2018
Table of Contents

1 Introduction
5 PMID
 [F] Diseases Research  / PubMed Research Articles  /
New arguments for beneficial effects of alpha-lipoic acid on the cardiovascular system in the course of type 2 diabetes.

PubMed

 

Resource

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences Feb ; ()

Authors

Dworacka M1; Chukanova G2; Iskakova S3; Kurmambayev Y4; Wesołowska A5; Frycz BA6; Jagodziński PP7; Dworacki G8;

Author Information
  • 1Department of Pharmacology, Poznan University of Medical Sciences, Rokietnicka 5d, 60-805 Poznań, Poland. Electronic address: mdworac@ump.edu.pl.
  • 2Department of Pharmacology, West Kazakhstan Marat Ospanov State Medical University, Mareshev str. 68, Aktobe 030019, Kazakhstan.
  • 3Department of Pharmacology, West Kazakhstan Marat Ospanov State Medical University, Mareshev str. 68, Aktobe 030019, Kazakhstan.
  • 4Department of Pharmacology, West Kazakhstan Marat Ospanov State Medical University, Mareshev str. 68, Aktobe 030019, Kazakhstan.
  • 5Department of Pharmacology, Poznan University of Medical Sciences, Rokietnicka 5d, 60-805 Poznań, Poland.
  • 6Department of Biochemistry and Molecular Biology, Poznań University of Medical Sciences, Święcickiego 6, 60-781 Poznań, Poland.
  • 7Department of Biochemistry and Molecular Biology, Poznań University of Medical Sciences, Święcickiego 6, 60-781 Poznań, Poland. Electronic address: pjagodzi@amp.edu.pl.
  • 8Department of Clinical Immunology, Poznań University of Medical Sciences, Rokietnicka 5a, 60-805 Poznań,Poland. Electronic address: frydrychowicz@ump.edu.pl.

Abstract

PURPOSE: Alpha-lipoic acid (ALA), widely known as an antioxidant, modifies also serum levels of angiogenic factors in type 2 diabetic patients. These pharmacological activities may influence the status of the cardiovascular system. Taking into consideration that diabetes is related to the increased cardiovascular risk we investigated several effects of ALA on angiogenic factors in the myocardium and in the aortal wall using a rat model of type 2 diabetes.

METHODS: Diabetes was induced in Wistar rats by a fat-rich diet and by intraperitoneal injection of a small dose of streptozotocin (30 mg/kg). Animals were divided into 3 groups: ALA-treated type 2 diabetes rat model, placebo-treated type 2 diabetes rat model and placebo-treated non-diabetic rats. ALA was administered orally once a day, 20 mg/kg, for 8 consecutive weeks. mRNA VEGF, VEGF-R1 and VEGF-R2 expression was measured in the myocardium and the aortal wall, simultaneously with circulating VEGF and circulating endothelial cells (cEC) and endothelial progenitor cells (cEPC).

RESULTS: ALA induced pro-angiogenic effect in the myocardium of rats with diabetes increasing mRNA VEGF expression and decreasing mRNA VEGFR-1 expression, while in the aortal wall ALA increased mRNA VEGFR-2 and VEGFR-1 expression. cVEGF in the ALA-treated group was higher comparing to both control groups. It was revealed that cEC percentage in the ALA-treated group was decreased with no effect on the percentage of cEPC.

CONCLUSIONS: In summary, the current data provide novel findings about potential beneficial effects of ALA on angiogenic factors in the cardiovascular system, especially on myocardium, in the course of type 2 diabetes .

Copyright © 2017. Published by Elsevier B.V.

PMID

29427700

Others

Publication Type: Journal Article


This article is licensed under the the National Library of Medicine License. It uses material from the PubMed National Library of Medicine Data.


Last Modified:   2016-03-27


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