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Monday, February 12th, 2018
Table of Contents

1 Introduction
5 PMID
 [F] Diseases Research  / PubMed Research Articles  /
Correlations of the glycemic variability with oxidative stress and erythrocytes membrane stability in patients with type 1 diabetes under intensive treatment.

PubMed

 

Resource

Diabetes research and clinical practice Feb ; ()

Authors

Rodrigues R1; Alves de Medeiros L2; Moreira Cunha L3; da Silva Garrote-Filho M4; Bernardino Neto M5; Tannus Jorge P6; Santos Resende E7; Penha-Silva N8;

Author Information
  • 1Faculty of Medicine, Federal University of Uberlândia, MG, Brazil. Electronic address: ricardo.rodrigues@ufu.br.
  • 2Institute of Genetics and Biochemistry, Federal University of Uberlândia, Uberlândia, MG, Brazil.
  • 3Institute of Genetics and Biochemistry, Federal University of Uberlândia, Uberlândia, MG, Brazil.
  • 4Institute of Genetics and Biochemistry, Federal University of Uberlândia, Uberlândia, MG, Brazil.
  • 5Department of Basic and Environmental Sciences, University of São Paulo, Lorena, SP, Brazil.
  • 6Faculty of Medicine, Federal University of Uberlândia, MG, Brazil.
  • 7Faculty of Medicine, Federal University of Uberlândia, MG, Brazil.
  • 8Institute of Genetics and Biochemistry, Federal University of Uberlândia, Uberlândia, MG, Brazil.

Abstract

OBJECTIVES: This study aimed to evaluate the correlations of glycemic variability with erythrocyte membrane stability parameters and oxidative stress markers in patients with DM1 under intensive treatment.

MATERIAL AND METHODS: 90 patients with DM1 and under intensive treatment of the disease were evaluated in relation to anthropometric indices, records of glycemic averages and parameters of glycemic variability, biochemical dosages (glucose, uric acid, lipidogram, glycated hemoglobin, microalbuminuria, creatinine and iron) reticulocyte count, erythrocyte membrane stability parameters and oxidative stress markers (thiobarbituric acid reactive substances, TBARS, and glutathione reductase, GR).

RESULTS: Indicators of glycemic variability in the short and long term showed correlations with parameters of membrane stability and markers of oxidative stress (GR). In addition, the comparison of these same parameters between the subgroups consisting of quartiles of GV or glycemic control also showed significant differences.

CONCLUSION: In the DM1 patients studied here, glycemic variability showed correlations with oxidative stress and erythrocyte membrane stability variables. This corroborates the hypothesis that glycemic fluctuations interfere with lipid peroxidation and cell membrane behavior, emphasizing its participation in mechanisms related to the development of chronic complications of diabetes.

Copyright © 2018 Elsevier B.V. All rights reserved.

PMID

29427698

Others

Publication Type: Journal Article


This article is licensed under the the National Library of Medicine License. It uses material from the PubMed National Library of Medicine Data.


Last Modified:   2016-03-27


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