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 [F] Diseases Research  / PubMed Research Articles  /
Skin complications of insulin injections: a case presentation and a possible explanation of hypoglycaemia.




Diabetes research and clinical practice Feb ; ()


Gentile S1; Strollo F2; Della Corte T3; Marino G4; Guarino G5; Italian Study Group on Injection Techniques6;

Author Information
  • 1Department of Internal Medicine, Campania University "Luigi Vanvitelli", Naples, Italy; Coordinator of the Study Group on Injection Technique of AMD (Medical Association of Diabetology). Electronic address: s.gentile1949@gmail.com.
  • 2Endocrinology and Diabetes, San Raffaele Termini Institute, Rome, Italy.
  • 3Department of Internal Medicine, Campania University "Luigi Vanvitelli", Naples, Italy.
  • 4Department of Internal Medicine, Campania University "Luigi Vanvitelli", Naples, Italy.
  • 5Department of Internal Medicine, Campania University "Luigi Vanvitelli", Naples, Italy.


We are willing to report the case of a woman with type 2 diabetes treated with insulin, 4 shots a day, referring to us for 2 very large pigmented abdominal lipo-hypertrophy (LH) areas due to incorrect injection technique. The ultrasound examination showed the presence offluidwithin both LH lesions. Fluid examination showed insulin concentrations 13 times higher thancirculating ones. A6-month longstructured training on correct injection techniques normalized metabolic control and took rid of all sudden severe hypoglycemic episodes and the wide glycemic variability. In fact, both LH areas disappeared became softer and slightly smaller and got fluid-free. This is the first case documenting the presence of sort of an insulin reservoir within LH lesions and fluid reabsorption can explain the disappearance of hypoglycemic episodes and the improvement of glycemic control.

Copyright © 2018 Elsevier B.V. All rights reserved.




Publication Type: Letter

This article is licensed under the the National Library of Medicine License. It uses material from the PubMed National Library of Medicine Data.

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