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Monday, February 12th, 2018
Table of Contents

1 Introduction
5 PMID
 [F] Diseases Research  / PubMed Research Articles  /
In vitro activities of kappa-carrageenan isolated from red marine alga Hypnea musciformis: Antimicrobial, anticancer and neuroprotective potential.

PubMed

 

Resource

International journal of biological macromolecules Feb ; ()

Authors

Souza RB1; Frota AF2; Silva J3; Alves C4; Neugebauer AZ5; Pinteus S6; Rodrigues JAG7; Cordeiro EMS8; de Almeida RR9; Pedrosa R10; Benevides NMB11;

Author Information
  • 1Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • 2Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • 3Marine Resources Research Group (GIRM), School of Tourism and Maritime Technology (ESTM), Polytechnic Institute of Leiria, Peniche, Portugal.
  • 4Marine Resources Research Group (GIRM), School of Tourism and Maritime Technology (ESTM), Polytechnic Institute of Leiria, Peniche, Portugal.
  • 5Marine Resources Research Group (GIRM), School of Tourism and Maritime Technology (ESTM), Polytechnic Institute of Leiria, Peniche, Portugal.
  • 6Marine Resources Research Group (GIRM), School of Tourism and Maritime Technology (ESTM), Polytechnic Institute of Leiria, Peniche, Portugal.
  • 7Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • 8Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • 9Department of Chemistry, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • 10Marine Resources Research Group (GIRM), School of Tourism and Maritime Technology (ESTM), Polytechnic Institute of Leiria, Peniche, Portugal.
  • 11Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Ceará, Brazil. Electronic address: nmbb@ufc.br.

Abstract

This study assessed the antioxidant, antimicrobial, cytotoxic, anticancer and neuroprotective activities of the kappa(k)-carrageenan isolated from the red alga Hypnea musciformis (Hm-SP). As expected, the chemical spectrum of the k-carrageenan from Hm-SP was confirmed by Fourier transform infrared (FT-IR) spectroscopy. Hm-SP revealed an antibacterial and antifungal action against Staphylococcus aureus and Candida albicans, respectively. Hm-SP did not promoted cytotoxic effects against Human breast cancer (MCF-7) and Human neuroblastoma (SH-SY5Y). However, it was observed a significant reduction of the cellular proliferation capacity in these cancer cells in presence of the Hm-SP. Furthermore, Hm-SP showed neuroprotective activity in 6-hydroxydopamine-induced neurotoxicity on SH-SY5Y cells by modulation of the mitochondria transmembrane potential and reducing Caspase 3 activity. In addition, Hm-SP demonstrates low antioxidant potential and did not induce significant cytotoxic effects or changes in the cell proliferation on Balb/c 3T3 mouse fibroblast cell-line. In summary, our data suggest that Hm-SP shows antimicrobial, antiproliferative and neuprotective activities.

Copyright © 2017. Published by Elsevier B.V.

PMID

29427681

Others

Publication Type: Journal Article


This article is licensed under the the National Library of Medicine License. It uses material from the PubMed National Library of Medicine Data.


Last Modified:   2016-03-27


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