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Friday, September 22nd, 2017
Table of Contents

1 Introduction
5 PMID
 [F] Diseases Research  / PubMed Research Articles  /
The impact of ovulation induction and ovarian stimulation on the risk of pregnancy-induced hypertension and on neonatal outcomes: A case/control study.

PubMed

 

Resource

European journal of obstetrics, gynecology, and reproductive biology 2017 Sep 12; 217()

Authors

Carbillon L1; Gronier H2; Cedrin-Durnerin I3; Pharisien I4; Nguyen MT5; Valensi P6; Cosson E7;

Author Information
  • 1Paris 13 University, Sorbonne Paris Cité, AP-HP, Jean Verdier Hospital, Department of Obstetrics and Gynecology, Bondy, France. Electronic address: lionel.carbillon@aphp.fr.
  • 2AP-HP, Jean Verdier Hospital, Department of Reproductive Medicine, Bondy, France.
  • 3AP-HP, Jean Verdier Hospital, Department of Reproductive Medicine, Bondy, France.
  • 4Paris 13 University, Sorbonne Paris Cité, AP-HP, Jean Verdier Hospital, Department of Obstetrics and Gynecology, Bondy, France.
  • 5Paris 13 University, Sorbonne Paris Cité, AP-HP, Jean Verdier Hospital, Department of Endocrinology-Diabetology-Nutrition, CRNH-IdF, Bondy, France.
  • 6Paris 13 University, Sorbonne Paris Cité, AP-HP, Jean Verdier Hospital, Department of Endocrinology-Diabetology-Nutrition, CRNH-IdF, Bondy, France.
  • 7Paris 13 University, Sorbonne Paris Cité, AP-HP, Jean Verdier Hospital, Department of Endocrinology-Diabetology-Nutrition, CRNH-IdF, Bondy, France; Paris 13 University, Sorbonne Paris Cité, UMR U1153 INSERM/U11125 INRA/CNAM/Université Paris13, Unité de Recherche Epidémiologique Nutritionnelle, Bobigny, France.

Abstract

OBJECTIVES: To study the role of ovarian stimulation procedures on the risk of pregnancy-induced hypertension, gestational diabetes mellitus and neonatal outcomes according to women's characteristics and the causes of infertility.

DESIGN: Retrospective, observational, case/control study.

PATIENTS: Spontaneous pregnancies (group A, n=8107), pregnancies achieved after mild ovarian ovulation induction without other Assisted Reproductive Technology (ART) procedures (group B, n=44), pregnancies after mild ovarian stimulation and ART procedures (group C, n=53) or pregnancies after multi (>2) follicular stimulation with gonadotrophin therapy and ART procedures (group D, n=133); all of the groups had identical protocols for prenatal care.

MAIN OUTCOME MEASUREMENTS: Pregnancy-induced hypertension (PIH), fetal macrosomia (estimated fetal weight >90th percentile), gestational diabetes mellitus, caesarean section, and neonatal outcomes.

RESULTS: The incidence rates of PIH (2.7, 11.6, 4.2, and 2.5%) in groups A, B, C and D, respectively, (p=0.004), fetal macrosomia (4.7, 7.0, 20.8, and 7.6%, respectively, p<0.001), caesarean section (21.8, 37.2, 21.7, and 17.6%, respectively, p=0.048), differed among the groups. The high incidence of PIH in pregnancies following ovulation induction was driven by polycystic ovarian syndrome (PCOS) per se.

CONCLUSION: PCOS per se was associated with more PIH, and ART procedures after mild mono/bi follicular ovarian stimulation were associated with more fetal macrosomia.

Copyright © 2017. Published by Elsevier B.V.

PMID

28898686

Others

Publication Type: Journal Article


This article is licensed under the the National Library of Medicine License. It uses material from the PubMed National Library of Medicine Data.


Last Modified:   2016-03-27


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