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 [F] Diseases Research  / PubMed Research Articles  /
MicroRNAs in the pathogenesis of type 2 diabetes: new research progress and future direction.




Canadian journal of physiology and pharmacology 2017 Sep 12; ()


Miao C1; Zhang G2; Xie Z3; Chang J4;

Author Information
  • 1Anhui Science and Technology University, 177515, Fengyang, Anhui, China ; miaocgastu@126.com.
  • 2School of Science and Technology of Tea and Food, Anhui Agricultural University, Hefei, China ; guoxuezhangah@126.com.
  • 3School of Science and Technology of Tea and Food, Anhui Agricultural University, Hefei, China ; xiezwahau@126.com.
  • 4Fourth Affiliated Hospital, Anhui Medical University, Hefei, China ; junchangah@126.com.


MicroRNA (miRNA) is a short non-coding RNA that can influence messenger RNA (mRNA) processing at the post-transcriptional level. A large number of miRNAs have been found in virtually all species so far, and these small molecules play an important role in many different physiological processes and various pathologic conditions, such as cell metabolism, cancer, autoimmune disease, and diabetes mellitus. Type 2 diabetes (T2D) arises from a dysregulated response to the elevated glucose level in the circulation. The prevalence of T2D has increased dramatically in all age groups, and T2D in older adults is associated with more T2D complications and higher mortality. T2D pathology is more complex, despite the existing finding describes the pathological mechanism, but the pathophysiology of the disease is still not fully elucidated. In this review, we summarize the current understanding of miRNA-mediated modulation of gene expression in T2D pathogenesis as well as related signaling pathways, and insight into the important role of miRNA in various T2D complications. Furthermore, the potential therapeutic value of miRNA for T2D patients is also detailed discussed.




Publication Type: Journal Article

This article is licensed under the the National Library of Medicine License. It uses material from the PubMed National Library of Medicine Data.

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