Ratiometric Optical Imaging of Subclinical Inflammation with a Thrombin-cleavable Probe: A Future Tool for the In Vivo Visualization of Clinically Silent Synovitis?
Arthritis & rheumatology (Hoboken, N.J.)
It is universally accepted that effective treatment of rheumatoid arthritis (RA) requires initiation of therapy at the early phase of articular inflammation. In addition to clinical and serological assessments, imaging of joint tissues provides useful information for the early diagnosis of RA (1). Although radiographic (X-ray) imaging can be used to detect bone erosions and to monitor disease progression in terms of bone involvement, X-ray does not detect early synovitis. This article is protected by copyright. All rights reserved.
- 1Section of Molecular Medicine, Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL, USA.
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||Last Modified: 2016-03-27