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Thursday, September 14th, 2017
Table of Contents

1 Introduction
5 PMID
 [F] Diseases Research  / PubMed Research Articles  /
Combination of capillaroscopic and ultrasonographic evaluations in systemic sclerosis: Results of a cross-sectional study.

PubMed

 

Resource

Arthritis care & research 2017 Sep 12; ()

Authors

Lescoat A1; Coiffier G2; de Carlan M3; Droitcourt C4; Ballerie A5; Claire C6; Perdriger A7; Patrick J8;

Author Information
  • 1Department of Internal Medicine, CHU Rennes, University of Rennes 1 all in Rennes, France.
  • 2Department of Rheumatology, CHU Rennes, University of Rennes 1 all in Rennes, France.
  • 3Department of Internal Medicine, CHU Rennes, University of Rennes 1 all in Rennes, France.
  • 4Department of Dermatology, CHU Rennes, University of Rennes 1, INSERM CIC 1414, Pharmacoepidemiology Unit, all in Rennes, France.
  • 5Department of Internal Medicine, CHU Rennes, University of Rennes 1 all in Rennes, France.
  • 6Department of Internal Medicine, CHU Rennes, University of Rennes 1 all in Rennes, France.
  • 7Department of Rheumatology, CHU Rennes, University of Rennes 1 all in Rennes, France.
  • 8Department of Internal Medicine, CHU Rennes, University of Rennes 1 all in Rennes, France.

Abstract

OBJECTIVES: To compare microvascular damages on nailfold capillaroscopy (NC) with macrovascular manifestations evaluated by hand power doppler ultrasonography (PDUS) in Systemic Sclerosis (SSc) patients, and to assess the associations of these damages with the main digital manifestations of the disease: digital ulcers (DU), acro-osteolysis and Calcinosis.

METHODS: NC, hand X-Rays and PDUS were systematically performed in 64 unselected SSc patients. PDUS evaluation with assessment of ulnar artery occlusion (UAO) and finger pulp blood flow (FPBF) was performed blinded for the results of X-Rays and NC.

RESULTS: UAO and pathologic FPBF were associated with severe capillary loss (<4 capillaries/mm) on NC (respectively OR=4.04 (1.23-13.29); p<0.05 and OR=3.38 (1.03-11.05); p<0.05). DU history was associated with UAO (OR=10.71 (3.36-34.13); p<0.0001), pathologic FPBF (OR=7.67 (2.52-23.28); p<0.0001), late pattern (OR=6.33 (2.03-19.68; p=0.001) and severe capillary loss (OR=8.52 (2.15-33.78); p=0.001). Acro-osteolysis was also associated with UAO (OR=15.83 (3.95-63.54); p<0.0001), pathologic FPBF (5.52 (1.71-17.90) p=0.003), late NC pattern (OR=6.86 (2.18-21.53); p=0.001) and severe capillary loss (OR=7.20 (2.16-24.02), p=0.001). Calcinosis on X-rays were associated with late NC pattern (OR=5.41 (1.82-16.12); p=0.002), severe capillary loss (OR=12.69 (3.14-51.26); p<0.0001) and UAO (OR=3.19 (1.14-8.92); p=0.025). Combination of UAO and severe capillary loss in a same patient was especially associated with DU history (OR=18.60 (2.24-154.34); p=0.001) and acro-osteolysis (OR=10.83 (2.56-45.88); p=0.001).

CONCLUSIONS: Microvascular damages evaluated by NC and macrovascular features like UAO assessed by PDUS show concordant associations with the main digital manifestations of the disease. This article is protected by copyright. All rights reserved.

This article is protected by copyright. All rights reserved.

PMID

28898558

Others

Publication Type: Journal Article


This article is licensed under the the National Library of Medicine License. It uses material from the PubMed National Library of Medicine Data.


Last Modified:   2016-03-27


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