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Friday, September 22nd, 2017
Table of Contents

1 Introduction
5 PMID
 [F] Diseases Research  / PubMed Research Articles  /
Endogenous lipid antigens for invariant Natural Killer T cells hold the reins in adipose tissue homeostasis.

PubMed

 

Resource

Immunology 2017 Sep 12; ()

Authors

van Eijkeren RJ1; Krabbe O2; Boes M3; Schipper HS4; Kalkhoven E5;

Author Information
  • 1Department of Molecular Cancer Research and Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.
  • 2Department of Molecular Cancer Research and Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.
  • 3Department of Pediatrics, Wilhelmina Children's Hospital, University Medical Center Utrecht, The Netherlands.
  • 4Department of Pediatrics, Wilhelmina Children's Hospital, University Medical Center Utrecht, The Netherlands.
  • 5Department of Molecular Cancer Research and Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.

Abstract

The global obesity epidemic and its associated co-morbidities, including type 2 diabetes, cardiovascular disease and certain types of cancers, have drawn attention to the pivotal role of adipocytes in health and disease. Besides their 'classical' function in energy storage and release, adipocytes interact with adipose-tissue resident immune cells, among which lipid-responsive invariant Natural Killer T (iNKT) cells. iNKT cells are activated by lipid antigens presented by antigen-presenting cells (APC) as CD1d/lipid complexes. Upon activation, iNKT cells can rapidly secrete soluble mediators that either promote or oppose inflammation. In lean adipose tissue, iNKT cells elicit a predominantly anti-inflammatory immune response, while obesity is associated with declining iNKT cell numbers. Recent work showed that adipocytes act as non-professional APC for lipid antigens. Here, we discuss endogenous lipid antigen processing and presentation by adipocytes, and speculate on how these lipid antigens together with 'environmental factors' such as tissue/organ environment and co-stimulatory signals are able to influence the fate of AT-resident iNKT cells, and thereby the role of these cells in obesity and its associated pathologies. This article is protected by copyright. All rights reserved.

This article is protected by copyright. All rights reserved.

PMID

28898395

Others

Publication Type: Journal Article, Review


This article is licensed under the the National Library of Medicine License. It uses material from the PubMed National Library of Medicine Data.


Last Modified:   2016-03-27


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