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Tuesday, June 27th, 2017
Table of Contents

1 Introduction
5 PMID
 [F] Diseases Research  / PubMed Research Articles  /
Antihypertensive and vasodilator effects of methanolic extract of Inula viscosa: Biological evaluation and POM analysis of cynarin, chlorogenic acid as potential hypertensive.

PubMed

 

Resource

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Jun 17; 93()

Authors

Hakkou Z1; Maciuk A2; Leblais V3; Bouanani NE4; Mekhfi H5; Bnouham M6; Aziz M7; Ziyyat A8; Rauf A9; Hadda TB10; Shaheen U11; Patel S12; Fischmeister R13; Legssyer A14;

Author Information
  • 1Laboratoire de Physiologie et Ethnopharmacologie URAC40, Faculté des Sciences, Université Mohammed Premier, Oujda, Morocco.
  • 2Laboratoire de Pharmacognosie UPRES-A 8076 CNRS, BIOCIS, Faculté de Pharmacie Université Paris Sud XI Chatenay Malabry, France.
  • 3Laboratoire de Signalisation et Physiopathologie Cardiaque INSERM UMR-S 769, Faculté de Pharmacie Université Paris Sud XI Chatenay Malabry, France.
  • 4Laboratoire de Physiologie et Ethnopharmacologie URAC40, Faculté des Sciences, Université Mohammed Premier, Oujda, Morocco.
  • 5Laboratoire de Physiologie et Ethnopharmacologie URAC40, Faculté des Sciences, Université Mohammed Premier, Oujda, Morocco.
  • 6Laboratoire de Physiologie et Ethnopharmacologie URAC40, Faculté des Sciences, Université Mohammed Premier, Oujda, Morocco.
  • 7Laboratoire de Physiologie et Ethnopharmacologie URAC40, Faculté des Sciences, Université Mohammed Premier, Oujda, Morocco.
  • 8Laboratoire de Physiologie et Ethnopharmacologie URAC40, Faculté des Sciences, Université Mohammed Premier, Oujda, Morocco.
  • 9Department of Chemistry, University of Swabi, Anbar 23561, Khyber Pakhtunkhwa, Pakistan. Electronic address: mashaljcs@yahoo.com.
  • 10Laboratoire de Chimie des Matériaux, Faculté des Sciences , Département de Chimie, Université Mohammed Premier , Oujda 60000, Morocco.
  • 11Department of Pharmacognosy, Faculty of Pharmacy, Umm Al-Qura University, Makkah-21955, Saudi Arabia.
  • 12Bioinformatics and Medical Informatics Research Center, San Diego State University, San Diego, 92182, USA.
  • 13Laboratoire de Signalisation et Physiopathologie Cardiaque INSERM UMR-S 769, Faculté de Pharmacie Université Paris Sud XI Chatenay Malabry, France.
  • 14Laboratoire de Physiologie et Ethnopharmacologie URAC40, Faculté des Sciences, Université Mohammed Premier, Oujda, Morocco. Electronic address: a.legssyer@ump.ac.ma.

Abstract

BACKGROUND: Inula viscosa L. (Asteraceae) is a medicinal plant widely used as a folk medicine in oriental Morocco, to treat hypertension. The antihypertensive effect of the methanolic extract obtained from I. viscosa leaves was evaluated in hypertensive L-NAME rats. Systolic blood pressure (SBP) was measured using a non-invasive indirect tail-cuff plethysmographic method. Four groups of rats were used: a control group; a hypertensive group treated with L-NAME (32mg/kg/day); a positive control group treated with L-NAME plus enalapril (15mg/kg/day) as a reference antihypertensive agent; and a group treated with L-NAME plus MeOH-extract (40mg/kg/day).

METHODS: Treatment with L-NAME alone caused a progressive increase in SBP. After 4 weeks, the value of SBP reached 160±2mmHg which shows the installation of hypertension. Enalapril prevented the increase in SBP, which remained normal at 123±1mmHg after 4 weeks of treatment. The administration of MeOH-extract along with L-NAME prevented the increase in SBP as well, which remained constant at 115±1mmHg after 4 weeks of treatment. In ex-vivo models, MeOH-extract produced a relaxation of pre-contracted ring aorta (54 ± 2% of relaxation at 3g/L). But, when the rings were denuded, MeOH-extract failed to relax pre-contracted rings of aorta. Phytochemical study of I. viscosa MeOH-extract revealed the presence of phenolic compounds, such as cynarin and chlorogenic acid.

RESULTS: The present results suggest that I. viscosa MeOH-extract has an antihypertensive, predominantly mediated by an endothelium-dependent vasodilatory effect. Cynarin and chlorogenic acid, which have a strong vasorelaxant effect may be involved in the antihypertensive effect of the plant extract. The bioinformatic POM analysis confirms the therapeutic potential of cynarin and chlorogenic acids as inhibitors of various biotargets. Based on the results, the coordination of these phytochemicals with calcium and transition metals should be studied, for better scope at antihypertensive drug development.

Copyright © 2017 Elsevier Masson SAS. All rights reserved.

PMID

28623784

Others

Publication Type: Journal Article


This article is licensed under the the National Library of Medicine License. It uses material from the PubMed National Library of Medicine Data.


Last Modified:   2016-03-27


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