www.diseases-diagnosis.com Homepage Diseases Symptoms Diseases Diagnosis Diseases Treatment Diseases Living Care Diseases Prevention Diseases Research
www
Search
Tuesday, June 27th, 2017
Table of Contents

1 Introduction
5 PMID
 [F] Diseases Research  / PubMed Research Articles  /
The role of PON-1, GR, IL-18, and OxLDL in depression with and without posttraumatic stress disorder.

PubMed

 

Resource

Pharmacological reports : PR 2017 Mar 17; 69(5)

Authors

Ogłodek EA1;

Author Information
  • 1Department of Psychiatry, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Toruń, Poland. Electronic address: e.oglodek@wp.pl.

Abstract

BACKGROUND: Both oxidative stress markers and inflammatory markers are important when diagnosing depression. Oxidative stress occurs due to an imbalance between free radical generation and antioxidant potential. Both adenosine triphosphate and reactive oxygen/nitrogen species are released during oxidative phosphorylation. When neuroinflammation and free radical production are increased, oxidative stress occurs and causes damage to all major cellular macromolecules. The aim of the study was to compare the concentrations of paraoxonase-1 (PON-1), glutathione reductase (GR), interleukin-18 (IL-18), and oxidized low-density lipoproteins (OxLDL) in depressed patients with and without posttraumatic stress disorder (PTSD), and PTSD alone.

METHODS: The number of participants was 460, including 230 males and 230 females. Each study group involved 60 subjects (30 males and 30 females). These were patients with mild depression (MD), moderate depression (MOD), severe depression (SeD), MD and PTSD (MD+PTSD), MOD and PTSD (MOD+PTSD), SeD and PTSD (SeD+PTSD), and with PTSD alone. The control group comprised 40 individuals (20 males and 20 females). At 7:00 a.m. all patients had blood samples collected to determine serum PON-1, GR, IL-18, and OxLDL concentrations using the ELISA test.

RESULTS: Depression became more severe as GR, IL-18 and OxLDL concentrations increased and PON-1 concentrations decreased.

CONCLUSION: All studied parameters can be considered markers of chronic stress in the above cases. They can be useful when making an early diagnosis and evaluating disease severity. Changes in the concentration levels of GR, IL-18, PON-1, and OxLDL may constitute a biological response to oxidative stress typical of depression.

Copyright © 2017 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.

PMID

28623707

Others

Publication Type: Journal Article


This article is licensed under the the National Library of Medicine License. It uses material from the PubMed National Library of Medicine Data.


Last Modified:   2016-03-27


Search
All informatin on the site is © www.diseases-diagnosis.com 2002-2016. Last revised: March 27, 2016
Are you interested in our site or/and want to use our information? please read how to contact us and our copyrights.
To let us provide you with high quality information, you can help us by making a more or less donation: