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Tuesday, June 27th, 2017
Table of Contents

1 Introduction
5 PMID
 [F] Diseases Research  / PubMed Research Articles  /
Juvenile social isolation affects maternal care in rats: involvement of allopregnanolone.

PubMed

 

Resource

Psychopharmacology 2017 Jun 17; ()

Authors

Pisu MG1; Boero G2; Biggio F3; Garau A4; Corda D5; Congiu M6; Concas A7; Porcu P8; Serra M9;

Author Information
  • 1Neuroscience Institute, National Research Council of Italy (CNR), Cagliari, Italy. m.g.pisu@in.cnr.it.
  • 2Department of Life and Environment Sciences, Section of Neuroscience and Anthropology, University of Cagliari, 09100, Cagliari, Italy.
  • 3Department of Life and Environment Sciences, Section of Neuroscience and Anthropology, University of Cagliari, 09100, Cagliari, Italy.
  • 4Department of Life and Environment Sciences, Section of Neuroscience and Anthropology, University of Cagliari, 09100, Cagliari, Italy.
  • 5Department of Life and Environment Sciences, Section of Neuroscience and Anthropology, University of Cagliari, 09100, Cagliari, Italy.
  • 6Department of Life and Environment Sciences, Section of Neuroscience and Anthropology, University of Cagliari, 09100, Cagliari, Italy.
  • 7Neuroscience Institute, National Research Council of Italy (CNR), Cagliari, Italy.
  • 8Neuroscience Institute, National Research Council of Italy (CNR), Cagliari, Italy.
  • 9Neuroscience Institute, National Research Council of Italy (CNR), Cagliari, Italy.

Abstract

RATIONALE: Social isolation of rats immediately after weaning is thought to represent an animal model of anxiety-like disorders. Socially isolated virgin females showed a significant decrease in allopregnanolone levels, associated with increased anxiety-related behavior compared with group-housed rats.

OBJECTIVES: The present study investigates whether post-weaning social isolation affects maternal behavior and assesses neuroactive steroid levels in adult female rats during pregnancy and postpartum.

RESULTS: Socially isolated dams displayed a reduction in the frequency of arched back nursing (ABN) behavior compared to group-housed dams. In addition, both total and active nursing were lower in socially isolated dams compared to group-housed dams. Compared to virgin females, pregnancy increases allopregnanolone levels in group-housed as well as isolated dams and such increase was greater in the latter group. Compared to pregnancy levels, allopregnanolone levels decreased after delivery and this decrease was more pronounced in isolated than group-housed dams. Moreover, the fluctuations in plasma corticosterone levels that occur in late pregnancy and during lactation follow a different pattern in socially isolated vs. group-housed rats.

CONCLUSIONS: The present results show that social isolation in female rats decreases maternal behavior; this effect is associated with lower allopregnanolone concentrations at postpartum, which may account, at least in part, for the poor maternal care observed in socially isolated dams. In support of this conclusion is the finding that finasteride-treated dams, which display a decrease in plasma allopregnanolone levels, also showed a marked reduction in maternal care, suggesting that allopregnanolone may contribute to the quality of maternal care.



PMID

28623385

Others

Publication Type: Journal Article


This article is licensed under the the National Library of Medicine License. It uses material from the PubMed National Library of Medicine Data.


Last Modified:   2016-03-27


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